Preheat oven to 400F. Cook pasta according to package directions; drain.
Meanwhile, cook bacon in large ovenproof skillet over medium heat until crisp; drain. Add onion, garlic and 1 teaspoon oregano to skillet; cook and stir about 3 minutes or until onion is tender. Stir in tomato sauce and hot pepper sauce. Add cooked pasta and cheese to skillet; stir to coat.
Combine bread crumbs, remaining 1 teaspoon oregano and melted butter in small bowl; sprinkle over pasta mixture. Bake about 5 minutes or until hot and bubbly. Garnish, if desired.